Desonide cream can cause side effects such as a cough, upper respiratory infection, increase blood pressure, and redness, irritation or burning at the site of application. Long-term use of desonide should be avoided because of an increased risk of HPA axis suppression. Desonide is not intended for oral, ophthalmic, or intravaginal use. Desonide cream and ointment should not be used by people with a known hypersensitivity or allergy to desonide or ingredients in the formulation. Desonide and alcohol use should be avoided. Prior to using desonide, it is necessary to speak with a pharmacist and medical provider to discuss potential side effects.