What is Humira used for? Humira belongs to a class of medications known as tumor necrosis factor (TNF) blockers (similar to Enbrel). Specifically, Humira (adalimumab) is a human IgG1 monoclonal antibody synthesized using recombinant DNA technology that binds to TNF-alpha, an inflammatory chemical that is found in places like joint fluids and psoriatic plaques in the body. Ultimately, the mechanism by which Humira works is not well understood. Humira is indicated in specific groups of patients with rheumatoid arthritis, psoriatic arthritis, Crohn’s disease and plaque psoriasis. After use of Humira, levels of inflammatory markers such as C-reactive protein and the erythrocyte sedimentation rate decreased.