Ibuprofen, including Advil and Motrin, can cause side effects when used. Side effects that can result from ibuprofen use include stomach upset, nausea, indigestion, cramps, rash, dermatitis, weight gain, edema and liver toxicity. Ibuprofen can increase the risk of serious cardiovascular thrombotic events, myocardial infarction, stroke, and serious gastrointestinal adverse events including bleeding, ulceration, and perforation of the stomach or intestines. Ibuprofen, Advil and Motrin should not be used at the same time as alcohol. People who have had a prior hypersensitivity or allergic reaction to ibuprofen or other NSAIDs should not use the generic or branded versions of the medication. Questions and concerns about using ibuprofen, Advil or Motrin should be directed to one’s pharmacist and medical provider before use.