Linaclotide, marketed under the name Linzess, is a medication used in adults in the treatment of irritable bowel syndrome with constipation (IBS-C) and chronic idiopathic constipation. Farmington Drugs & Medical Supplies provides patients who need Linzess prescriptions at our home pharmacy or via free local deliveries for prescription refills.
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What is Linzess used for? Linzess (linaclotide) belongs to a class of medications known as guanylate cyclase-C agonists and is a 14-amino acid peptide. Linzess is used in the management of constipation in adults with chronic idiopathic constipation and irritable bowel syndrome with constipation. Linaclotide, along with some of its metabolites, bind to the surface of the intestines, resulting in metabolic changes which increase the secretion of chloride and bicarbonate into the intestinal lumen. Through these secretions, linaclotide is thought to increase transit of fluids in the intestines and reduce pain. Following administration, the systemic availability of Linzess is low and plasma concentrations of linaclotide are not measurable. Some linaclotide is excreted in the stool.
Linzess – Side Effects
Linzess can cause side effects when used. Side effects of Linzess (linaclotide) use include diarrhea, flatulence, abdominal pain and abdominal distension. Linzess can also cause gastroesophageal reflux disease, fatigue and vomiting. Linzess and alcohol use should be avoided. It is recommended that anyone planning to use Linzess or linaclotide discuss possible side effects and other concerns with their pharmacist and medical provider before using the medication.
Linzess is expensive, costing approximately $15 per Linzess 145 mcg capsule when one is paying out of pocket for the medication. Linzess coupons may be available at times online or from the manufacturer. Farmington Drugs & Medical Supplies takes pride in offering the most cost efficient services and prescriptions to our patients.
Linzess capsules are linaclotide-coated beads in hard gelatin in addition to some inactive ingredients. Linzess capsules are orally administered and come in Linzess 145 mcg and Linzess 290 mcg capsules. Linzess 145 mcg capsules and Linzess 290 mcg capsules are white to off-white opaque hard gelatin capsules. Linaclotide itself is found as a white to off-white powder that is slightly soluble in water.
Given the evolving nature of medicine and science, this information might not be accurate and should not be construed as medical advice or diagnosis / treatment recommendations. Please consult a licensed medical provider if you have additional questions.